Tıp Fakültesi: Hacettepe Üniversitesi İng Tıp Fakültesi

Uzmanlık Eğitimi: Gazi Üniversitesi Tıp Fakültesi

Yurtdışı Deneyim: Zürih Üniversitesi Kardiyoloji Kliniği

Türk Kardiyoloji Derneği

Türk Tabipler Odası

Avrupa Kardiyoloji Derneği (FESC)

Avrupa Ateroskleroz Derneği (FEAS)

Amerikan Anjiyoloji Derneği (FASA)


1. INVEST - The International Verapamil SR/Trandolapril Study – Co-investigator

2. EXTRACT-TIMI 25 – The Enoxaparin and Thrombolysis Reperfusion for Acute Myocardial Infarction Treatment, Thrombolysis in Myocardial Infarction-Study 25 – Co-investigator

3. CURRENT (OASIS 7) – Randomized, Multinational, Double-Blind Study, Comparing a High Loading Dose Regimen of Clopidogrel Versus Standard Dose in Patients With Unstable Angina or Myocardial Infarction Managed With an Early Invasive Strategy. – Co-investigator

4. IMPROVE-IT – A Multicenter, Double-Blind, Randomized Study to Establish the Clinical Benefit and Safety of Vytorin (Ezetimibe/Simvastatin Tablet) vs Simvastatin Monotherapy in High-Risk Subjects Presenting With Acute Coronary Syndrome (IMProved Reduction of Outcomes: Vytorin Efficacy International Trial – IMPROVE IT) –Principal Investigator

5. TRA-CER TRIAL – “A Multi-center, RandomizedDouble-Blind, Placebo- Controlled Study to Evaluate the Safety and Efficacy of SCH 530348 in Addition to Standard of Care in Subjects With Acute Coronary Syndrome: Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome – National Leader – Steering Committee Member

6. APPRAISE – 2: A Phase 3, Randomized, Double-Blind, Evaluation of Safety and Efficacy of Apixaban In Subjects with a Recent Acute Coronary Syndrome. Phase 3 trial. Principal Investigator

7. A randomized, double-blind , triple-dummy trial, to compare otamixaban to Unfractionated Heparin + eptifibatide, in patients with Unstable angina/Non ST segment Elevation Myocardial infarction scheduled to undergo an early invasive strategy. Phase 3 trial. Principal Investigator

8.A Phase III, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Safety Study to Evaluate Cardiovascular Outcomes in Patients With Type 2 Diabetes Mellitus Treated with Dutogliptin. Phase 3 trial. Principal Investigator

9. A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate Cardiovascular  outcomes Following Treatment with Alogliptin in Addition to Standard of Care in Subjects with Type 2 Diabetes and Acute Coronary Syndrome. Phase 3 trial. National Leader – Steering Committee Member

10. A comparison of platelet inhibition following a prasugrel 60mg or prasugrel 30mg loading dose with or without pretreatment with a clopidogrel 600mg loading dose in patients with acute coronary syndromes (ACS) who are to undergo percutaneous coronary intervention (PCI). Phase 2 trial. National Leader – Steering Committee Member

11. SOLID-TIMI 52. A clinical outcomes study of Darapladib versus placebo in subjects following acute coronary syndrome to compare the incidence of major adverse cardiovascular events. Phase 3 trial. Principal Investigator

Yurt dışı yayınlar

A1. Alkan M, Yalçın R, Timurkaynak T, Metin M, Çengel A, Dörtlemez Ö, Dörtlemez H. Left Atrial Free Floating Thrombus. Jpn Heart J 36:399-404,1995 (ISSN : 0021-4868, SCI-Expanded)

A2. Timurkaynak T, Boyacı B, Çengel A, Dörtlemez Ö. Acute Occlusion of the Left Main Coronary Artery Following Intracoronary Ultrasound Examination. Cathet Cardiovasc Intervent 2000;49:234 ( ISSN : 1522-1946, SCI-Expanded)

A3. Timurkaynak T, Boyacı B, Çengel A, Dörtlemez Ö, Dörtlemez H. Early Clinical Experience With the Implantation of a Novel Synthetic Coronary Stent Graft. Cathet Cardiovasc Intervent 2000;50:265-266( ISSN : 1522-1946, SCI-Expanded)

A4. Timurkaynak T, Boyacı B, Cemri M, Çengel A, Dörtlemez H. Optimal Stent Positioning in Coronary Arteries: Partial Balloon Inflation to Overcome Cardiac Cycle-Related Motion of the Stent/Delivery System. Cathet Cardiovasc Intervent 2000;50:511-512( ISSN : 1522-1946, SCI-Expanded)

A5. Cemri M, Cengel A, Timurkaynak T. Pentacuspid aortic valve diagnosed by transesophageal echocardiography. Heart 2000;84):E9 (ISSN : 1355-6037, SCI-Expanded)

A6. Timurkaynak T, Cemri M, Ozdemir M, Yalcin R, Boyacı B, Çengel A, DörtlemezÖ, Dörtlemez H. Primary Angioplasty and Stenting in a Patient with Primary Antiphospholipid Syndrome, and Thrombocytopenia. J Invas Cardiol 2001;13:395-400 (ISSN : 1042-3931)

A7. Timurkaynak T, Cemri M, Ozdemir M, Yalcin R, Çengel A, Dörtlemez Ö. Intracoronary tirofiban infusion in a case with massive intracoronary thrombus. J Invas Cardiol 2001;13(9):654-6 (ISSN : 1042-3931)

A8. Timurkaynak TGoksen I, Çengel A, Dörtlemez Ö. Subacute stent thrombosis developing 12 days after discontinuation of ticlopidine therapy. J Invas Cardiol. 2001;13(9):640-3 (ISSN : 1042-3931)

A9. Ozdemir M, Timurkaynak T, Cemri M, Boyacı B, Yalcin R, Çengel A, Dörtlemez Ö, Dörtlemez H. Stenting of the Septal Perforator Coronary Artery. J Invas Cardiol. 2001 Oct;13(10):694-7 (ISSN : 1042-3931)

A10. Timurkaynak T, Ciftci H, Cemri M. Coronary Artery Perforation: a rare complication of coronary angiography. Acta Cardiol 2001; 56(5): 323-325 (ISSN : 0001 – 5385,  SCI – Expanded)

A11. Timurkaynak T, Ozdemir M, Ciftci H, Cemri M, Cengel A, Dortlemez O. Recanalization of an Occluded Major Side Branch After Stenting with Intracoronary Adenosine. Jpn Heart J 2002;43:43-48 (ISSN : 0021-4868, SCI-Expanded)

A12. Timurkaynak T, Ciftci H, Cengel A. Use of a 0,014 Inch Guidewire for Cannulation of Left Coronary Ostium with a Difficult Anatomy. J Invas Cardiol 2002;14:91-2 (ISSN : 1042-3931)

A13. Timurkaynak T, Ozdemir M, Cengel A, Cemri M, Ciftci H, Yalcin R, Boyacı B, Dörtlemez Ö, Dörtlemez H. Direct Stenting in Angiographically Apparent Thrombus Containing Lesions. J Invas Cardiol 2001;13:742-7 (ISSN : 1042-3931)

A14. Timurkaynak T, Ozdemir M, Cengel A, Ciftci H, Cemri M, Erdem G, Yalcin R, Boyacı B, Dörtlemez Ö, Dörtlemez H. Myocardial Injury After Apparently Successful Coronary Stenting with or without Balloon Dilation: Direct versus Conventional Stenting. J Invas Cardiol 2002;14:167-170 (ISSN : 1042-3931)

Ø  Commentary

Stephen G. Ellis

Incremental Progress? The Roles of Direct Stenting and Routine Troponin Measurement After Percutaneous Coronary Intervention

J Invas Cardiol 2002;14:171-172 (ISSN : 1042-3931)

A15. Cemri M, Timurkaynak T, Özdemir M, Boyacı B, Yalçın R, Çengel A, Dörtlemez Ö, Dörtlemez H. Effects of left ventricular systolic dysfunction on left atrial appendage and left atrial functions in patients with chronic nonvalvular atrial fibrillation. Acta Cardiol 2002;57:101-105 (ISSN : 0001 – 5385,  SCI – Expanded)

A16. Timurkaynak T, Ciftci H, Cengel A, Dortlemez O. Amplatzing a 6 Fr Judkins Right Guiding Catheter for Increased Success in Complex Right Coronary Artery Anatomy. Cathet Cardiovasc Intervent 2002;55:527-8 ( ISSN : 1522-1946, SCI-Expanded)

A17. Timurkaynak T, Ciftci H, Cengel A. Double Right Coronary Artery with Atherosclerosis: A Rare Coronary Artery Anomaly. J Invas Cardiol 2002;14:337-339 (ISSN : 1042-3931)

A18. Özdemir M, Timurkaynak T, Cemri M, Boyacı B, Yalçın R, Çengel A, Dörtlemez Ö, Dörtlemez H. Medium term follow-up of intermediate coronary stenoses left unrevascularized based on myocardial fractional flow reserve findings. Acta Cardiol ( ISSN : 0001 – 5385,  SCI – Expanded)

A19. Timurkaynak T, Ciftci H, Cengel A. Covered stent graft for primary PTCA of aortocoronary vein graft.Acta Cardiol 2002; 57: 305-308 (ISSN : 0001 – 5385,  SCI – Expanded)

A20. Timurkaynak T, Ciftci H, Ozdemir M, Cengel A, Cemri M, Kaya M, Yalcin R, Boyacı B, Dörtlemez Ö, Dörtlemez H. Frequency of cardiac troponin t elevation after successful direct stenting. Acta Cardiol 2002;57: 261-264 (ISSN : 0001 – 5385,  SCI – Expanded)

A21. Özdemir M, Erdem G, Türkoğlu S, Cemri M, Timurkaynak T, Boyacı B, Yalçın R, Çengel A, Dörtlemez Ö, Dörtlemez H. Head-to-head comparison of two different low-molecular-weight heparins in acute coronary syndrome : A Single center experience. Jpn Heart J ( ISSN : 0021 – 4868, SCI – Expanded)

A22. Timurkaynak T, Ozdemir M, Cengel A, Cemri M, Ciftci H, Yalcin R, Boyacı B, Dörtlemez Ö, Dörtlemez H. Conventional versus Direct stenting in acute myocardial infarction: Effect on immediate coronary blood flow. J Invas Cardiol 2002; 14:372-377 (ISSN : 1042-3931)

A23. Timurkaynak T, Aydogdu G, Cengel A. Acute myocardial infarction secondary to thyrotoxicosis. Acta Cardiol ( ISSN : 0001 – 5385,  SCI – Expanded)

A24. Timurkaynak T. Commentary. Clopidrogel is as effective as ticlopodine for reducing major adverse events following coronary stenting. Evidence-based Cardiovascular Medicine 2002; 6/3:113 (ISSN : 1361-2611)

Ø  Commentary to the article by;

Bhatt D, Bertrand M, Berger P, L’Allier P, Moussa I, Moses J, Dangas G, Taniuchi M, Lasala J, Holmes D, Ellis S, Topol E.

Meta-Analysis of Randomized and Registry Comparisons of Ticlopidine With Clopidogrel After Stenting. Journal of the American College of Cardiology 2002; 39:1

A25. Timurkaynak T, Ciftci H, Ozdemir M, Cengel A, Tavil Y, Kaya M, Erdem G, Cemri M, Dörtlemez Ö, Dörtlemez H. Side Branch Occlusion After Coronary Stenting With or Without Balloon Predilation: Direct Stenting Versus Conventional. J Invasive Cardiol. 2002;14(9):497-501 (ISSN : 1042-3931).

Ø  Commentary

A. Colombo; G.Stankovic

Sidebranch Patency During Main Branch Stenting: Try to Keep the Branch Open Immediate and Long-Term!   

Invasive Cardiol. 2002;14(9):503-504 (ISSN : 1042-3931).

A26. Ciftci H, Taçoy G, Timurkaynak T, Ozdemir M, Cemri M, Duraklıoglugil E, Yalcin R, Boyaci B, Cengel A. Effects of atorvastatin versus pravastatin on coronary artery stenosis after stent implantation. Brief communication. Acta Cardiol 2003;58:13-15 (ISSN: 0001-5385, SCI –Expanded)

A27. Ciftci H, Taçoy G, Tulmac M, Erdem G, Duraklıoglugil E, Timurkaynak T, Ozdemir M, Cemri M, Boyaci B, Yalcin R, Cengel A. Inflammatory response after percutaneous coronary interventions: direct versus conventional stenting. Brief communication. Acta Cardiol 2003;58:12-13 (ISSN: 0001-5385, SCI –Expanded)

A28. Erkan AF, Timurkaynak T, Cemri M, Ozdemir M, Boyaci B, Yalcin R, Cengel A. The safety and efficacy of t-PA combined with low-dose tirofiban vs t-PA alone in acute ST-segment elevation myocardial infarction. Brief communication. Acta Cardiol 2003;58:20-21 (ISSN: 0001-5385, SCI –Expanded)

A29. Ozdemir M, Timurkaynak T, Tulmac M, Cemri M, Boyaci B, Yalcin R, Cengel A, Dortlemez O, Dortlemez H.. Early and late outcome of stenting in a consecutive series of patients with coronary lesions in vessels less than 2.8mm in diameter. Jpn Heart J 2003;44:163-177 (ISSN: 0021-4868, SCI-Expanded)

A30. Yalcin R, Tacoy GA, Timurkaynak T, Cengel A. Dissection of the sinus of valsalva during coronary angiography in a patient with spontaneous coronary artery dissection. Anadolu Kardiyol Derg. 2003;3:194 (ISSN: 1302-8723)

A31. CNg E, Hakan Temiz N, Yldrm N, Timurkaynak T, CEngel A, UNlu M.  Detection of stent restenosis in single vessel CAD: comparison of 201Tl and gated 99mTc-MIBI SPECT. Nucl Med Commun. 2004;25:479-486

A32. Yalçin R, Kaya MG, Ozdemir M, Cemri M, Timurkaynak T, Boyaci B, Cengel A. Prospective randomized trial of transthoracic versus low-energy transvenous internal cardioversion in persistent atrial fibrillation. Acta Cardiol 2004;59:521-526 (ISSN: 0001-5385, SCI –Expanded)

A33. Sahinarslan A, Cengel A, Okyay K, Yazici HU, Elbey S, Cemri M, Ozdemir M, Timurkaynak T. B-type natriuretic peptide and extent of lesion on coronary angiography in stable coronary artery disease. Coron Artery Dis. 2005;16:225-9.

A34. Sahinarslan A, Cengel A, Biberoglu G, Hasanoglu A, Turkoglu S, Timurkaynak T. Plasma asymmetric dimethylarginine level and extent of lesion at coronary angiography. Coron Artery Dis. 2006;17:605-9.

A35. Yalçın R, Taçoy G, Timurkaynak T, Çengel A. Role of tirofiban in treatment of stent thrombosis – Scientific Letter. Anadolu Kardiyol Derg. 2006;6:180-181. (ISSN: 1302-8723)

A36. Arslan U, Balcıoğlu AS, Timurkaynak T, Çengel A. The clinical outcomes of percutaneous coronary intervention in chronic total coronary occlusion.  Int Heart Journal. Int Heart J. 2006;47:811-9.

A37. Turkoglu S, Arpag U, Timurkaynak T. Spontaneous coronary vasospasm in the catheterization laboratory: prompt resolution after atropine injection. Heart. 2007;93:215.

A38. Kaya MG, Yalçin R, Saygili A, Timurkaynak T, Cengel A. Coincidental diagnosis of corrected transposition of the great arteries in an asymptomatic 65-year-old patient. Anadolu Kardiyol Derg. 2007;7:101-2.

A39. Taçoy G, Sahinarslan A, Timurkaynak T. Spontaneous multivessel coronary artery dissection in a wrestler. Anadolu Kardiyol Derg. 2007;7:193-5.

A40. Arslan F, Kaya MG, van der Heijden G, Timurkaynak T, Cengel A. Hypertension as a predictor of adverse cardiac events in patients with borderline fractional flow reserve. Acta Cardiol. 2007;62:367-72.

A41. Ozdemir M, Yazici GE, Turkoglu S, Timurkaynak T, Cengel A. Metoprolol does not effect myocardial fractional flow reserve in patients with intermediate coronary stenoses. Int Heart J. 2007;48:477-83.

A42. Kaya MG, Arslan F, Abaci A, van der Heijden G, Timurkaynak T, Cengel A.  Myocardial blush grade: a predictor for major adverse cardiac events after primary PTCA with stent implantation for acute myocardial infarction. Acta Cardiol. 2007;62:445-51.

A43. Timurkaynak T, Arslan U, Balcioglu S, Turkoglu S. Long term tirofiban infusion before percutaneous coronary intervention in patients with angiographically massive intracoronary thrombus. Saudi Med J. 2008;29:42-7.

A44. Timurkaynak T, Balcioglu S, Arslan U, Kocaman SA, Cengel A. Plasma homocysteine level in cardiac syndrome X and its relation with duke treadmill score. Saudi Med J. 2008;29:364-7.

A45. Türkoğlu S, Timurkaynak T. E-page Original Images. The accordion phenomenon. Anadolu Kardiyol Derg. 2008 Apr 10;8:E12.

A46. Tacoy G, Balcioglu AS, Akinci S, Erdem G, Kocaman SA, Timurkaynak T, Cengel A. Traditional Risk Factors Are Predictive on Segmental Localization of Coronary Artery Disease. Angiology. 2008;59:402-7.

A47. Kocaman SA, Sahinarslan A, Biberoglu G, Hasanoglu A, Akyel A, Timurkaynak T, Cengel A. Asymmetric dimethylarginine and coronary collateral vessel development. Coron Artery Dis. 2008;19:469-74

A48.Turkoglu S, Ozdemir M, Tacoy G, Tavil Y, Abaci A, Timurkaynak T, Cengel A.  Corrected thrombolysis in myocardial infarction frame counts in diabetic patients with angiographically normal coronary arteries. Saudi Med J. 2008;29:1164-7.

A49.Turkoglu S, Simsek V, Timurkaynak T. Intracoronary Thrombus Aspiration through a Guiding Catheter in a Case with Stent Thrombosis. J Invasive Cardiol. 2008;20:E304-5.

A50. Kaya MG, Okyay K, Yazici H, Sen N, Tavil Y, Turkoglu S, Timurkaynak T, Ozdemir M, Cemri M, Yalcin R, Cengel A. Long term clinical effects of magnetic resonance imaging in patients with coronary artery stent implantation. Coron Artery Dis. 2009 Mar;20(2):138-42.

A51. Sahinarslan A, Kocaman SA, Olgun H, Kunak T, Kiziltunç E, Ozdemir M, Timurkaynak T. The reliability of fractional flow reserve measurement in patients with diabetes mellitus. Coron Artery Dis. 2009;20:317-21.

A52. Tacoy G, Yazici GE, Erden M, Timurkaynak T. The comparison of early and late outcome of direct and conventional stenting of patients with st elevation myocardial infarction. Ther Adv Cardiovasc Dis. 2009;3:181-6.

A53. Kocaman SA, Sahinarslan A, Arslan U, Timurkaynak T. The delta fractional flow reserve can predict lesion severity and long-term prognosis. Atherosclerosis. 2009;203(1):178-84.

A54. Yazici G, Erden M, Tacoy G, Yavuz B, Turkoglu S, Timurkaynak T. The Optimal Time of Elective Percutaneous Coronary Intervention for Stable Patients After ST Elevation Myocardial Infarction. Angiology. 2009;60:67-73.

A55. Şahinarslan A, Kocaman SA, Hizal F, Timurkaynak T. The impact of multivessel disease on fractional flow reserve. Acta Cardiol. 2009 Feb;64(1):79-83.

A56. Kocaman SA, Sahinarslan A, Cemri M, Timurkaynak T, Boyaci B, Cengel A. Independent Relationship of Serum Uric Acid Levels with Leukocytes and Coronary Atherosclerotic Burden has been accepted for publication in Nutrition, Metabolism & Cardiovascular Diseases. Nutrition, Metabolism & Cardiovascular Diseases (baskıda)

A57. Kocaman SA, Sahinarslan A, Akyel A, Timurkaynak T, Boyaci B, Cengel A. The Association of Circulating Monocyte Count with Coronary Collateral Growth in Patients with Diabetes Mellitus. Acta Diabetologica (in press)

A58. Tacoy G, Timurkaynak T. Hipertansiyon tedavisinde geliştirilen ilaçlar ve yeni tedavi yöntemleri. Türkiye Klinikleri Journal of Cardiovascular Sciences (in press)

A59.Harrington RA, Van de Werf F, Armstrong PW, Aylward P, Park B, Veltri E, Mahaffey KW, Moliterno DJ, Strony J, Wallentin L, White HD, Diaz R, Aylward P, Huber K, Van de Werf F, Nicolau JC, Armstrong PW, Prieto JC, Isaza D, Widimsky P, Grande P, Nieminen M, Montalescot G, Bode C, Wong L, Ofner P, Lewis BS, Ambrosio G, Valgimigli M, Ogawa H, Yamaguchi J, Jukema JW, Cornel JH, White HD, Nordrehaug JE, Ruzyllo W, Providencia L, Tan HC, Dalby A, Seung-Jung P, Betriu A, Cequier A, Held C, Pfisterer M, Chen MF, Timurkaynak T, Storey RF, Chen E, Harrington RA, Hudson MP, Lincoff AM, Mahaffey KW, Morrow DA, Tricoci P, Whellan D. The Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome (TRA*CER) trial: study design and rationale. Am Heart J. 2009;158(3):327-334.e4.

A60. Sahinarslan A, Kocaman SA, Yazici E, Turfan M, Ozdemir M, Timurkaynak T. Impact of the lesion location on fractional flow reserve. Acta Cardiol. 2009;64:761-5.

A61. Timurkaynak T. What is renin inhibition? Mechanism of action. Turk Kardiyol Dern Ars. 2009 Oct;37 Suppl 7:5-14.

A62. Taçoy G, Timurkaynak T. Transradial approach in diagnostic and therapeutic interventional coronary artery procedures. Turk Kardiyol Dern Ars. 2010;38:50-6.

A63. Sahinarslan A, Kocaman SA, Topal S, Ercin U, Bukan N, Yalcin R, Timurkaynak T.  Relation between serum monocyte chemoattractant protein-1 and coronary collateral development. Coron Artery Dis. 2010 Dec;21(8):455-9.

A64. Kocaman SA, Yalçın MR, Yağcı M, Sahinarslan A, Türkoğlu S, Arslan U, Kurşunluoğlu N, Ozdemir M,Timurkaynak T, Cemri M, Abacı A, Boyacı B, Cengel A. Endothelial progenitor cells (CD34+KDR+) and monocytes may provide the development of good coronary collaterals despite the vascular risk factors and extensive atherosclerosis. Anadolu Kardiyol Derg. 2011 Jun;11(4):290-9.

A65. Sahinarslan A, Kocaman SA, Bas D, Akyel A, Ercin U, Zengin O, Timurkaynak T. Plasma neutrophil gelatinase-associated lipocalin levels in acute myocardial infarction and stable coronary artery disease. Coron Artery Dis. 2011 Aug;22(5):333-8.

A66. Sahinarslan A, Kocaman SA, Topal S, Erçin U, Bukan N, Timurkaynak T. The relation of serum monocyte chemoattractant protein-1 level with coronary atherosclerotic burden and collateral degree in stable coronary artery disease Turk Kardiyol Dern Ars. 2011 Jun;39(4):269-75.

A67. Kocaman SA, Sahinarslan A, Kunak T, Balcioğlu S, Cetin M, Cemri M, Timurkaynak T, Boyaci B, Cengel A. The particular interactions of the traditional cardiovascular risk factors with different circulating specific leukocyte subtype counts in blood: an observational study. Anadolu Kardiyol Derg. 2011 Nov;11(7):573-81.

A68. Thrombin-receptor antagonist vorapaxar in acute coronary syndromes. N Engl J Med. 2012 Jan 5;366(1):20-33.